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With a demonstrated efficacy and safety profile, fibryga® is an effective option when needing fibrinogen replacement.1-6 Click below to review the clinical data giving confidence to clinicians like you to use fibryga®.
Fibryga® is indicated as treatment of bleeding episodes and perioperative prophylaxis in patients with congenital hypo- or afibrinogenaemia with bleeding tendency.
It is also indicated for complementary therapy to management of uncontrolled severe haemorrhage in patients with acquired hypofibrinogenaemia in the course of surgical intervention.
UK-FIB-2500024 | May 2026
Abbreviations
AFD, acquired fibrinogen deficiency; CFD, congenital fibrinogen deficiency.
References
Lissitchkov T, et al. Fibrinogen concentrate for treatment of bleeding and surgical prophylaxis in congenital fibrinogen deficiency patients. J Thromb Haemost. 2020;18:815–24.
Djambas Khayat C, et al. Efficacy and safety of fibrinogen concentrate for on-demand treatment of bleeding and surgical prophylaxis in paediatric patients with congenital fibrinogen deficiency. Haemophilia. 2021;27:283–92.
Roy A, et al. Efficacy of fibrinogen concentrate in major abdominal surgery - A prospective, randomized, controlled study in cytoreductive surgery for pseudomyxoma peritonei. J Thromb Haemost. 2020;18:352–63.
Callum J, et al. Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial. JAMA. 2019:322:1966– 76.
Ayaganov D, et al. Prospective, randomized study of fibrinogen concentrate versus cryoprecipitate for correcting hypofibrinogenemia in cardiac surgery patients. J Cardiothor Vasc Anesthesia. 2024;38:80–5
Ross C, et al. Pharmacokinetics, clot strength and safety of a new fibrinogen concentrate: randomized comparison with active control in congenital fibrinogen deficiency. J Thromb Haemost. 2018;16:253–61.
